Han S. Choe
Bio-University of Ulsan College of Medicine, Asan Medical Center, Korea
Han S. Choe, PhD
Birth Date: Oct. 10, 1967
Gender: Male
Marital Status: Married with two daughters
Citizenship: South Korea
Position: Professor
Work: Department of Physiology, Bio-Medical Institute of Technology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-Ro 43-Gil,Seoul, 138-736 South Korea
Work Phone : +82 (2) 3010-4292
Cellular Phone : +82 (10) 9811-4292
Work Fax : +82 (2) 3010-8148
E-mail: [email protected], [email protected], [email protected]
Website: https://sites.google.com/site/biodruglab
Map: https://goo.gl/maps/3Z4CEkgeKUis8NKm7
Employment:
2013-Pres. University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Department of Physiology, Professor
2012-2013 University of California at San Diego, La Jolla, CA
Skaggs School of Pharmatheutical Sciences
Visiting Scholar (host: Ruben Abagyan, PhD)
2008-2013 University of Ulsan College of Medicine, Seoul, South Korea.
Department of Physiology, Associate Professor
2004-2008 University of Ulsan College of Medicine, Seoul, South Korea.
Department of Physiology, Assistant Professor
2002-2004 University of Ulsan College of Medicine, Seoul, South Korea.
Department of Physiology, Full time lecturer
1993-1994 Pohang University of Science and Technology, Pohang, Korea
Lab technician (Supervisor: Chin O. Lee, PhD)
1991-1992 Obligatory military serivice as a second lieutenant
Education:
- Chonbuk National University, Chonju, Korea,
Department of Pharmacology&Institute of Cardiovascular Research
Postdoctoral Fellow (Supervisor: Soowan Chae, MD PhD)
- The Salk Institute for Biological Studies,La Jolla, CA, USA
Structural Biology Laboratory, Postdoctoral Fellow (Supervisor: Senyon Choe, PhD)
- Cornell University Weill Medical College, New York, NY.
Dept. Physiology and Biophysics
Postdoctoral Fellow (Supervisor: Lawrence G. Palmer, PhD)
1994-1999 Cornell University Weill Graduate School of Medical Sciences, New York, NY 10021, USA PhD: Biophysics (Thesis advisor: Lawrence G. Palmer, PhD)
1994-1994 Pohang University of Science and Technology, Pohang, Korea
6 months in PhD course: Biophysics (Thesis advisor: Chin O. Lee, PhD)
1989-1991 Seoul National University Graduate School of Natural Science, Seoul, Korea
MS : Neurobiology (Thesis advisor: Man S. Kang, PhD)
Courses taken: Biology of Membranes, Advanced Cell and Molecular Biology, Special Lectures in Biochemistry, Advanced Genetics, Methods in Molecular Biology, Advanced Physiology, Special Lectures in Molecular Genetics
1985-1989 Seoul National University College of Natural Science, Seoul, Korea
BS: Zoology
Courses taken: Mathematics, Calculus, Ordinary Differential Equations, Linear Algebra, Engineering Mathematics, Statistics, Introduction to Logics, Biophysics, Physical Chemistry, Chemistry & Lab., Organic Chemistry, Biochemistry, Molecular Biology, Cell and Molecular Biology, Biology & Lab., Cell Biology, Developmental Biology, Genetics, Immunology, Developmental Physiology, Animal Physiology, Radiation Biology, Physiology, Systematics, Ecology, Introduction to Psychology
Research Interests:
∙ Developing new protein/peptide drugs
∙ Differentiating human pluripotent stem cell into various cells
∙ Solving protein crystal structures and computer simulation of biomacromolecules
∙ Understanding the mechanism of HERG channel block by various drugs
Research Skills:
∙ Electrophysiology: patch clamp, two-electrode voltage clamp, kinetic modeling
∙ X-ray crystallography:crystallization, data collection, structure modeling
∙ Computer simulation of biomacromolecules: protein structure prediction, molecular dynamics, virtual screening, 3D-QSAR
∙ Programming languages: Python, C and Basic.
∙ Proteomics: 2-dimensional electrophoresis and identifying protein spots using database search
∙ Molecular biology: chimera and mutant gene construction, protein overexpression in bacteria, yeast and insect cell system and purification
∙ Misc.: fluorescence ratio imaging, single cardiomyocyte isolation, ion-selective electrode, andanimal cell culture.
Academic Research & Teaching Experience:
2012-2013 Visiting Scholar, University of California San Diego, CA, USA
2002-Pres. University of Ulsan College of Medicine, Seoul, South Korea.
Department of Physiology
Research: Developing new bio-drugs, solving protein crystal structures, and investigating the mechanism of HERG channel block by various drugs.
Teaching: Teachs medical student and graduate school students for biological sciences on physiology and biophysics.
2001-2002 Chonbuk National University, Chonju, Korea, Department of Pharmacology&Institute of Cardiovascular Research
Research: Investigated changes of protein expression level in epileptic brain, asthmatic lung, HIF-stimulated cell line using proteomics technique. And also trying to find proteins interacting with Kv1.5, junctin, or CRAC proteins using immunoprecipitation and proteomics technique.
1999-2001 The Salk Institute for Biological Studies, La Jolla, CA, Structural Biology Lab.
Research: Investigated the method of improving expression level of voltage-gated potassium channels in heterologously-expressed system and the structure of gelsolin using X-ray crystallography technique.
1994-1999 Cornell University Graduate School of Medical Science, New York, NY.
Research: Investigated the relationship between the structure and the function of inwardly rectifying potassium channels using electrophysiological techniques.
Teaching: Lead Journal Club classes for medical students in a human structure and function course.
1993-1994 Pohang University of Science and Technology, Pohang, Korea
Research: Measured intracellular ion concentrations of single cardiomyocyte using the ion-selective electrode technique and the fluorescence ratio imaging technique.
1989-1991 Seoul National University, Graduate School of Natural Science, Seoul, Korea
Research: Studied effects of growth factors on the proliferation and differentiation of telencephalonic neuroblasts in vitro.
Teach: Lead experiments for undergraduate students in a general biology course.
Administrative Experience:
2016-Pres. Chairman, Department of Physiology
2014-Pres. Director, Bio-Medical Institute of Technology
2010-2012 Chairman, Department of Physiology
Service to Academic Community:
2009-2011 Officer of Korean Biophysical Society
2006 Officer of Korean Society for Biochemistry and Molecular Biology
2003 Reviewer of Molecules and Cells
2000 Reviewer of the Journal of Molecular Neuroscience
1998-2000 Reviewer of the Journal of General Physiology
Academic and Professional Honors:
2014 Professor of the year in research, University of Ulsan College of Medicine
2000-2002 Postdoctoral fellowship, American Heart Association
2000 Research fellowship, the National Kidney Foundation
1999 The Robert F. Pitts Award for distinguished research, Cornell University Medical College
Society Membership:
2014-Pres. Korean Society for Stem Cell Research
2007-Pres. Korean Society for Biotechnology and Bioengineering
2007-Pres. Korean Society for Microbiology and Biotechnology
2005-Pres. Korean Society for Brain and Neuroscience
2005-Pres. Korean Society for Biochemistry and Molecular Biology
2002-Pres. Korean Biophysical Society
2002-Pres. Korean Society for Molecular and Cellular Biology
1999-Pres. American Physiological Society
1999-Pres. Biophysical Society
1999-Pres. Neuroscience society
Thesis:
- Choe, H. (1991) Effects of insulin-like growth factor I and thyroid hormone on the proliferation and differentiation of chick embryonic telencephalonic neuroblasts. Graduate School of Seoul National University, Seoul, Korea (M.S. Thesis).
- Choe, H. (1999) Structure-function relationships of inward-rectifier K+ channels. Cornell University Weill Graduate School of Medical Sciences, New York, NY (PhD thesis).