Han S. Choe

Bio-University of Ulsan College of Medicine, Asan Medical Center, Korea

 

Han S. Choe, PhD

Birth Date:                    Oct. 10, 1967

Gender:                         Male

Marital Status:              Married with two daughters

Citizenship:                  South Korea

Position:                       Professor

Work:                           Department of Physiology, Bio-Medical Institute of Technology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-Ro 43-Gil,Seoul, 138-736 South Korea

Work Phone :               +82 (2) 3010-4292

Cellular Phone :            +82 (10) 9811-4292

Work Fax :                   +82 (2) 3010-8148

E-mail:                          hchoe@amc.seoul.kr, hchoe@ulsan.ac.kr, hanchoe@gmail.com

Website:                       https://sites.google.com/site/biodruglab

Map:                            https://goo.gl/maps/3Z4CEkgeKUis8NKm7

 

 

Employment:

2013-Pres.        University of Ulsan College of Medicine,  Asan Medical Center, Seoul, Korea.

Department of Physiology, Professor

2012-2013       University of California at San Diego, La Jolla, CA

Skaggs School of Pharmatheutical Sciences

Visiting Scholar (host: Ruben Abagyan, PhD)

2008-2013        University of Ulsan College of Medicine, Seoul, South Korea.

Department of Physiology, Associate Professor

2004-2008       University of Ulsan College of Medicine, Seoul, South Korea.

Department of Physiology, Assistant Professor

2002-2004       University of Ulsan College of Medicine, Seoul, South Korea.

Department of Physiology, Full time lecturer

1993-1994       Pohang University of Science and Technology, Pohang, Korea

Lab technician (Supervisor: Chin O. Lee, PhD)

1991-1992       Obligatory military serivice as a second lieutenant

 

Education:

  • Chonbuk National University, Chonju, Korea,

Department of Pharmacology&Institute of Cardiovascular Research

Postdoctoral Fellow (Supervisor: Soowan Chae, MD PhD)

  • The Salk Institute for Biological Studies,La Jolla, CA, USA

Structural Biology Laboratory,  Postdoctoral Fellow (Supervisor: Senyon Choe, PhD)

  • Cornell University Weill Medical College, New York, NY.

Dept. Physiology and Biophysics

Postdoctoral Fellow (Supervisor: Lawrence G. Palmer, PhD)

1994-1999       Cornell University Weill Graduate School of Medical Sciences, New York, NY 10021, USA PhD: Biophysics (Thesis advisor: Lawrence G. Palmer, PhD)

1994-1994       Pohang University of Science and Technology, Pohang, Korea

6 months in PhD course: Biophysics (Thesis advisor: Chin O. Lee, PhD)

1989-1991       Seoul National University Graduate School of Natural Science, Seoul, Korea

MS : Neurobiology (Thesis advisor: Man S. Kang, PhD)

Courses taken: Biology of Membranes, Advanced Cell and Molecular Biology, Special Lectures in Biochemistry, Advanced Genetics, Methods in Molecular Biology, Advanced Physiology, Special Lectures in Molecular Genetics

1985-1989       Seoul National University College of Natural Science, Seoul, Korea

BS: Zoology

Courses taken: Mathematics, Calculus, Ordinary Differential Equations, Linear Algebra, Engineering Mathematics, Statistics, Introduction to Logics, Biophysics, Physical Chemistry, Chemistry & Lab., Organic Chemistry, Biochemistry, Molecular Biology, Cell and Molecular Biology, Biology & Lab., Cell Biology, Developmental Biology, Genetics, Immunology, Developmental Physiology, Animal Physiology, Radiation Biology, Physiology, Systematics, Ecology, Introduction to Psychology

 

Research Interests:    

∙ Developing new protein/peptide drugs

∙ Differentiating human pluripotent stem cell into various cells

∙ Solving protein crystal structures and computer simulation of biomacromolecules

∙ Understanding the mechanism of HERG channel block by various drugs

 

Research Skills:         

∙ Electrophysiology: patch clamp, two-electrode voltage clamp, kinetic modeling

∙ X-ray crystallography:crystallization, data collection, structure modeling

∙ Computer simulation of biomacromolecules: protein structure prediction, molecular dynamics, virtual screening, 3D-QSAR

∙ Programming languages: Python, C and Basic.

∙ Proteomics: 2-dimensional electrophoresis and identifying protein spots using database search

∙ Molecular biology: chimera and mutant gene construction, protein overexpression in bacteria, yeast and insect cell system and purification

∙ Misc.: fluorescence ratio imaging, single cardiomyocyte isolation, ion-selective electrode, andanimal cell culture.

 

Academic Research & Teaching Experience:

2012-2013        Visiting Scholar, University of California San Diego, CA, USA

2002-Pres.        University of Ulsan College of Medicine, Seoul, South Korea.

Department of Physiology

Research: Developing new bio-drugs, solving protein crystal structures, and investigating the mechanism of HERG channel block by various drugs.

Teaching: Teachs medical student and graduate school students for biological sciences on physiology and biophysics.

2001-2002      Chonbuk National University, Chonju, Korea, Department of Pharmacology&Institute of Cardiovascular Research

Research: Investigated changes of protein expression level in epileptic brain, asthmatic lung, HIF-stimulated cell line using proteomics technique. And also trying to find proteins interacting with Kv1.5, junctin, or CRAC proteins using immunoprecipitation and proteomics technique.

1999-2001      The Salk Institute for Biological Studies, La Jolla, CA, Structural Biology Lab.

Research: Investigated the method of improving expression level of voltage-gated potassium channels in heterologously-expressed system and the structure of gelsolin using X-ray crystallography technique.

1994-1999       Cornell University Graduate School of Medical Science, New York, NY.

Research: Investigated the relationship between the structure and the function of inwardly rectifying potassium channels using electrophysiological techniques.

Teaching: Lead Journal Club classes for medical students in a human structure and function course.

1993-1994       Pohang University of Science and Technology, Pohang, Korea

Research: Measured intracellular ion concentrations of single cardiomyocyte using the ion-selective electrode technique and the fluorescence ratio imaging technique.

1989-1991       Seoul National University, Graduate School of Natural Science, Seoul, Korea

Research: Studied effects of growth factors on the proliferation and differentiation of telencephalonic neuroblasts in vitro.

Teach: Lead experiments for undergraduate students in a general biology course.

 

Administrative Experience:

2016-Pres.        Chairman, Department of Physiology

2014-Pres.        Director, Bio-Medical Institute of Technology

2010-2012        Chairman, Department of Physiology

 

Service to Academic Community:

2009-2011        Officer of Korean Biophysical Society

2006                Officer of Korean Society for Biochemistry and Molecular Biology

2003                Reviewer of Molecules and Cells

2000                Reviewer of the Journal of Molecular Neuroscience

1998-2000       Reviewer of the Journal of General Physiology

 

Academic and Professional Honors:

2014                Professor of the year in research, University of Ulsan College of Medicine

2000-2002       Postdoctoral fellowship, American Heart Association

2000                Research fellowship, the National Kidney Foundation

1999                The Robert F. Pitts Award for distinguished research, Cornell University Medical  College

 

Society Membership:

2014-Pres.        Korean Society for Stem Cell Research

2007-Pres.        Korean Society for Biotechnology and Bioengineering

2007-Pres.        Korean Society for Microbiology and Biotechnology

2005-Pres.        Korean Society for Brain and Neuroscience

2005-Pres.        Korean Society for Biochemistry and Molecular Biology

2002-Pres.        Korean Biophysical Society

2002-Pres.        Korean Society for Molecular and Cellular Biology

1999-Pres.        American Physiological Society

1999-Pres.        Biophysical Society

1999-Pres.        Neuroscience society

 

Thesis:

  1. Choe, H. (1991) Effects of insulin-like growth factor I and thyroid hormone on the proliferation and differentiation of chick embryonic telencephalonic neuroblasts. Graduate School of Seoul National University, Seoul, Korea (M.S. Thesis).
  2. Choe, H. (1999) Structure-function relationships of inward-rectifier K+ channels. Cornell University Weill Graduate School of Medical Sciences, New York, NY (PhD thesis).
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